A novel exogenous concentration-gradient collagen scaffold augments full-thickness articular cartilage repair
نویسندگان
چکیده
منابع مشابه
Histopathological Effects of Loading on Cartilage Repair in a Rat Full-thickness Articular Cartilage Defect Model
[Purpose] We investigated effects of loading on cartilage repair in rat full-thickness articular cartilage defects and histopathologically analyzed the healing process of the defect. [Subjects] A total of 40 male 9-week-old Wistar rats were used. [Methods] Full-thickness articular cartilage defects were created over the capsule at the loading portion in the medial condyle of the femur. Twenty r...
متن کاملA three-dimensional osteochondral composite scaffold for articular cartilage repair.
There is a recognized and urgent need for improved treatment of articular cartilage defects. Tissue engineering of cartilage using a cell-scaffold approach has demonstrated potential to offer an alternative and effective method for treating articular defects. We have developed a unique, heterogeneous, osteochondral scaffold using the TheriForm three-dimensional printing process. The material co...
متن کاملSpontaneous repair of full-thickness defects of articular cartilage in a goat model. A preliminary study.
BACKGROUND Full-thickness defects measuring 3 mm in diameter have been commonly used in studies of rabbits to evaluate new procedures designed to improve the quality of articular cartilage repair. These defects initially heal spontaneously. However, little information is available on the characteristics of repair of larger defects. The objective of the present study was to define the characteri...
متن کاملThe Effect of Hyaluronic Acid on a Rabbit Model of Full Thickness Articular Cartilage Repair
Introduction Knee injuries are common in both the young and the athletic populations. While ligamentous and meniscal trauma constitute the majority of knee injuries, articular cartilage damage can and does occur frequently. Early detection of articular cartilage damage has dramatically improved with the advent of MRI, and focal defects as small as 1mm may now be detected(1). “Benign neglect” ha...
متن کاملIn Vivo Evaluation of a Novel Oriented Scaffold-BMSC Construct for Enhancing Full-Thickness Articular Cartilage Repair in a Rabbit Model.
Tissue engineering (TE) has been proven usefulness in cartilage defect repair. For effective cartilage repair, the structural orientation of the cartilage scaffold should mimic that of native articular cartilage, as this orientation is closely linked to cartilage mechanical functions. Using thermal-induced phase separation (TIPS) technology, we have fabricated an oriented cartilage extracellula...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2008
ISSN: 1063-4584
DOI: 10.1016/j.joca.2008.02.003